Giuseppe Poli Selected Research

4-hydroxy-2-nonenal (4-hydroxynonenal)

2/2021	Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis.
12/2018	Up-regulation of COX-2 and mPGES-1 by 27-hydroxycholesterol and 4-hydroxynonenal: A crucial role in atherosclerotic plaque instability.
10/2017	Oxysterols and 4-hydroxy-2-nonenal contribute to atherosclerotic plaque destabilization.
8/2015	Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability.
11/2012	Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal.
11/2005	4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis.
1/2005	4-hydroxynonenal and TGF-beta1 concur in inducing antiproliferative effects on the CaCo-2 human colon adenocarcinoma cell line.
1/2005	Role of 4-hydroxy-2,3-nonenal in the pathogenesis of fibrosis.

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Giuseppe Poli Research Topics

Disease

30	Inflammation (Inflammations) 01/2024 - 08/2002
15	Atherosclerosis 02/2021 - 11/2005
13	Alzheimer Disease (Alzheimer's Disease) 05/2021 - 01/2009
10	Neoplasms (Cancer) 01/2024 - 01/2005
10	Atherosclerotic Plaque (Atheroma) 02/2021 - 01/2005
8	Chronic Disease (Chronic Diseases) 10/2018 - 01/2005
7	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2019 - 01/2007
7	Hypercholesterolemia 01/2015 - 06/2008
6	Rupture 02/2021 - 08/2011
6	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2019 - 11/2007
5	Infections 01/2023 - 01/2017
5	Fibrosis (Cirrhosis) 01/2010 - 01/2004
4	Neuroinflammatory Diseases 05/2021 - 01/2014
4	Carcinogenesis 10/2017 - 05/2008
4	Colonic Neoplasms (Colon Cancer) 03/2013 - 01/2005
3	Neuroblastoma 06/2014 - 09/2003
3	Necrosis 11/2012 - 12/2003
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2022 - 11/2019
2	COVID-19 05/2022 - 01/2020
2	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2012
2	Disease Progression 05/2021 - 12/2016
2	Virus Diseases (Viral Diseases) 10/2018 - 12/2014
2	Non-alcoholic Fatty Liver Disease 01/2018 - 10/2016
2	Fatty Liver 10/2016 - 01/2004
2	Dementia (Dementias) 01/2015 - 07/2012
2	Amyloid Plaque 07/2012 - 06/2011
2	Vascular Remodeling 06/2009 - 04/2009
2	Carcinoma (Carcinomatosis) 11/2007 - 01/2005
2	Cholestasis 01/2007 - 03/2004
2	Ischemia 09/2003 - 03/2002
1	Communicable Diseases (Infectious Diseases) 01/2024
1	Heart Failure 11/2022
1	Atrial Fibrillation 11/2022
1	Prostatic Neoplasms (Prostate Cancer) 01/2022
1	Chronic Hepatitis B 01/2021
1	Adrenocortical Carcinoma 01/2020
1	Common Cold 01/2020
1	Gastroenteritis 10/2018
1	Rotavirus Infections 10/2018
1	Alcoholic Fatty Liver 01/2018

Drug/Important Bio-Agent (IBA)

32	OxysterolsIBA 01/2024 - 11/2005
31	CholesterolIBA 05/2021 - 11/2005
17	LipidsIBA 02/2021 - 01/2005
10	27-hydroxycholesterolIBA 01/2022 - 06/2011
10	LDL Lipoproteins (beta Lipoproteins)IBA 02/2021 - 01/2005
10	CytokinesIBA 01/2018 - 11/2002
9	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 01/2005
8	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 02/2021 - 01/2005
7	Amyloid (Amyloid Fibrils)IBA 05/2021 - 01/2011
6	AldehydesIBA 02/2021 - 01/2005
6	Proteins (Proteins, Gene)FDA Link 02/2021 - 03/2004
6	AntioxidantsIBA 03/2015 - 03/2004
5	oxidized low density lipoproteinIBA 12/2018 - 01/2005
4	Peptides (Polypeptides)IBA 05/2021 - 01/2011
4	Matrix Metalloproteinases (MMPs)IBA 02/2021 - 08/2011
4	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2017
4	Transforming Growth Factor beta1 (TGF beta 1)IBA 04/2009 - 01/2005
3	NF-kappa B (NF-kB)IBA 07/2010 - 02/2005
2	7-ketocholesterolIBA 05/2021 - 01/2020
2	Peptide Hydrolases (Proteases)FDA Link 02/2021 - 12/2016
2	25-hydroxycholesterolIBA 01/2021 - 10/2018
2	ChemokinesIBA 01/2018 - 11/2012
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 11/2013
2	Toll-Like Receptor 4IBA 08/2015 - 01/2014
2	Interleukin-8 (Interleukin 8)IBA 08/2015 - 01/2012
2	QuercetinIBA 01/2014 - 06/2011
2	Metalloproteases (Metalloproteinases)IBA 01/2014 - 08/2011
2	24-hydroxycholesterolIBA 01/2014 - 06/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2013 - 01/2012
2	EnzymesIBA 03/2013 - 02/2005
2	Cardiolipins (Cardiolipin)IBA 01/2007 - 03/2004
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2006 - 01/2005
2	AcidsIBA 01/2005 - 12/2003
2	Glutathione (Reduced Glutathione)IBA 03/2004 - 09/2003
2	Oxygen (Dioxygen)IBA 09/2003 - 08/2002
2	NitrogenIBA 09/2003 - 08/2002
1	NucleosidesIBA 01/2023
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 11/2022
1	Dietary Fats (Dietary Fat)IBA 11/2022
1	Estrogen ReceptorsIBA 01/2022
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 02/2021
1	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 02/2021
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 02/2021
1	SubtilisinIBA 02/2021
1	Mitotane (Lysodren)FDA Link 01/2020
1	Catechin (Z 7300)IBA 05/2019
1	Toll-Like Receptors (Toll-Like Receptor)IBA 05/2019
1	TanninsIBA 05/2019
1	Dinoprostone (PGE2)FDA Link 12/2018
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2018
1	InterleukinsIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 08/2015
1	p38 Mitogen-Activated Protein KinasesIBA 04/2015
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2014
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2014
1	Prostaglandin-E SynthasesIBA 01/2014
1	Free Radical ScavengersIBA 01/2014

Therapy/Procedure

4	Therapeutics 05/2022 - 01/2009
2	Liver Transplantation 03/2004 - 03/2002